β-Cyclodextrin-complexed (−)-linalool produces antinociceptive effect superior to that of (−)-linalool in experimental pain protocols
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منابع مشابه
Enantiospecifi c ( S ) - ( + ) - Linalool Formation from β - Myrcene by Linalool Dehydratase - Isomerase
In enzyme-catalyzed processes, the reaction pathway is defi ned by the enzyme and its complex with the substrate. The active site of an enzyme structure determines the interaction with the substrate which often results in high stereospecifi city. Classical examples are the reduction of nicotinamide-adenine-dinucleotides (NAD and NADP) and of aldehydes, the hydration of fumarate, and aldose-keto...
متن کاملLinalool Biotransformation with Fungi
Different fungal strains were screened for their ability to convert linalool into valuable flavour compounds. Aspergillus niger DSM 821, Botrytis cinerea 5901/02 and Botrytis cinerea 02/FBII/2.1 produced isomers of lilac aldehyde and lilac alcohol via 8hydroxylinalool as postulated intermediate. Linalool oxides and 8-hydroxylinalool accumulated as major products during fungal linalool biotransf...
متن کاملIdentification of a Plastid-Localized Bifunctional Nerolidol/Linalool Synthase in Relation to Linalool Biosynthesis in Young Grape Berries
Monoterpenoids are a diverse class of natural products and contribute to the important varietal aroma of certain Vitis vinifera grape cultivars. Among the typical monoterpenoids, linalool exists in almost all grape varieties. A gene coding for a nerolidol/linalool (NES/LINS) synthase was evaluated in the role of linalool biosynthesis in grape berries. Enzyme activity assay of this recombinant p...
متن کاملStructure and evolution of linalool synthase.
Plant terpene synthases constitute a group of evolutionarily related enzymes. Within this group, however, enzymes that employ two different catalytic mechanisms, and their associated unique domains, are known. We investigated the structure of the gene encoding linalool synthase (LIS), an enzyme that uses geranyl pyrophosphate as a substrate and catalyzes the formation of linalool, an acyclic mo...
متن کاملEffect of linalool on the acquisition and reinstatement of morphine-induced conditioned place preference in mice
Objective: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice.Material and Methods: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 4...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2013
ISSN: 1742-7835
DOI: 10.1111/bcpt.12087